Ginger is known to have anti-inflammatory and anti-oxidative effects, making it a popular herbal supplement to treat inflammatory diseases.
And according to a Michigan Medicine led study published in JCI Insight, the main bio-active compound of ginger root, 6-gingerol, is therapeutic in countering the mechanism that fuels certain autoimmune diseases in mice. Researchers specifically looked at lupus, a disease which attacks the body’s own immune system, and its often associated condition anti-phospholipid syndrome, which causes blood clots, since both cause widespread inflammation and damage organs overtime.
In mice with either anti-phospholipid syndrome or lupus, 6-gingerol prevented neutrophil extracellular trap release, which is triggered by the auto-antibodies that these diseases produce.
“Neutrophil extracellular traps, or NETs, come from white blood cells called neutrophils,” says lead author Ramadan Ali, Ph.D. “These sticky spider-web like structures are formed when auto-antibodies interact with receptors on the neutrophil’s surface.”
According to Ali, these webs play an important role in the pathogenesis of lupus and anti-phospholipid syndrome where they trigger auto-antibody formation and contribute to blood vessel clotting and damage.
The study question was, “will the anti-inflammatory properties of ginger extend to neutrophils, and specifically, can this natural medicine stop neutrophils from making NET’s that contribute to disease progression?”
“This pre-clinical study in mice offers a surprising and exciting, ‘yes’,” Ali says.
Ali discovered that after giving 6-gingerol, the mice had lower levels of NET’s. Their tendency to make clots was also drastically reduced and 6-gingerol appeared to inhibit neutrophil enzymes called phosphodiesterases, which in turn reduced neutrophil activation.
But the most surprising find of all was that the mice, regardless of whether they had anti-phospholipid syndrome or lupus, had reduced auto-antibodies suggesting the inflammatory cycle, auto-antibodies stimulating NET’s which stimulate more auto-antibodies, was broken.
Next steps and potential implications
“Through my years of medical training I wasn’t taught much about supplements, but it’s something that so many patients ask me about,” says study author and rheumatologist Jason Knight, M.D. “When Ramadan brought the concept to me, I was enthusiastic to pursue it in my lab, as I knew it would matter to them. Sometimes our patients give us really good ideas!”
Although the study was done in mouse models, Ali and Knight think the preclinical data, showing that 6-gingerol has anti-neutrophil properties that may protect against autoimmune disease progression, encourages clinical trial development.
“As for basically all treatments in our field, one size does not fit all. But, I wonder if there is a subgroup of autoimmune patients with hyperactive neutrophils who might benefit from increased intake of 6-gingerol,” Knight says. “It will be important to study neutrophils before and after treatment so we can determine the subgroup most likely to see benefit.”
The bioactive compound can’t be the primary therapy for someone with active anti-phospholipid syndrome or lupus, but the team is interested to see if the natural supplement may help those at high risk for disease development.
“Those that have auto-antibodies, but don’t have activated disease, may benefit from this treatment if 6-gingerol proves to be a protective agent in humans as it does in mice,” Ali says, who’s passionate about natural medicine research for rheumatic diseases.
“Patients with active disease take blood thinners, but what if there was also a natural supplement that helped reduce the amount of clots they produce? And what if we could decrease their auto-antibodies?”
