While being hailed as a major tool in the fight against COVID, medical experts are warning of some dangerous drug interactions with Pfizer’s new antiviral drug, Paxlovid. And the same could be true about Merck’s new COVID relief medication.
NBC News recently reported that one of the two drugs in Pfizer’s Paxlovid “antiviral cocktail” could cause severe or life-threatening interactions with commonly used medications, including statins, blood thinners, and some antidepressants and the FDA does not recommend Paxlovid for those with severe kidney or liver disease.
In addition, due to concerns about the potential side effects of Merck’s molnupiravir, the FDA has restricted its use to adults and only in cases in which other treatments are inaccessible or are not ”clinically appropriate.”
The main concern is that when Paxlovid is paired with other medications that are also metabolized by the CYP3A enzyme, the ritonavir component in the mix may boost the specified co-administered drugs to toxic levels.
The drugs that pose interaction risks are widely prescribed to those at the greatest risk from COVID because of other health conditions, said Peter Anderson, a professor of pharmaceutical sciences at the University of Colorado Anschutz Medical Campus.
He told NBC News that ”some of these potential interactions are not trivial, and some pairings have to be avoided altogether,” adding that ”some are probably easily managed, but some we’re going to have to be very careful about.”
The FDA has published in its Paxlovid fact sheet a list of medications that may interact harmfully with ritonavir, including those that should not be paired with the COVID antivirals.
Pharmacists emphasize, however, that many of the drug interactions are manageable and should not preclude most people from taking Paxlovid.
Emily Zadvorny, a clinical pharmacist who is the executive director of the Colorado Pharmacists Society, told NBC News that pharmacists ”are an excellent source of information and advice about interactions between medications and also supplements and herbal products,” adding that ”they will help determine if a significant interaction exists and devise solutions to mitigate the interaction if possible.”
Experts are also hopeful that since the Paxlovid treatment is brief, 30 pills, taken as three pills twice a day for five days, the risk of adverse interactions with other medications is actually quite low. However, consumers need to be aware of these potentially dangerous interactions, and like with any medication, make sure your prescribing physician is aware of all other medications and supplements you may be taking.
