A group of researchers from China has successfully tested an experimental injection capable of slowing down the aging processes in the body.
The researchers from the Chinese Academy of Sciences and Capital Medical University introduced a new type of human stem cell called senescence-resistant mesenchymal progenitor cells (SRCs) by reprogramming the genetic pathways associated with longevity. These cells, which resist aging and stress without developing tumors, were tested on elderly crab-eating macaques (a type of primate), which share physiological similarities with humans in their 60s and 70s.
The created drug activates the immune system, targeting it to destroy senescent cells. This is what they call aging cells that have lost the ability to divide but still persist or accumulate in tissues, disrupting their function. The introduction of genetically modified stem cells resistant to signs of aging made it possible to achieve a pronounced rejuvenating effect.
According to the authors of the study, during the 12-week tests, there was an improvement in the condition of the brain, memory, muscle tissue, reproductive function, and a number of internal organs.
Key Takeaways From This Study:
The researchers admit that this study is considered an early-stage breakthrough and emphasize the need for larger clinical trials to confirm the long-term safety and effectiveness of the approach in humans. For now, here are some key takeaways from their study.
- How it works: The SRCs target and destroy aging cells (senescent cells) that accumulate in tissues and disrupt normal function.
- Animal model: Elderly macaques, physiologically similar to humans in their 60s and 70s, were used for the 44-week experiment.
- Results: The injections led to comprehensive rejuvenation in the macaques, improving brain and muscle function, memory, and skin and hair condition.
- Safety: No negative side effects, such as fever, weight loss, or immune overreactions, were observed during the study
You can read the complete study, Senescence-resistant human mesenchymal progenitor cells counter aging in primates, published in the journal Cell, by clicking on the link.