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Calorie Restriction Rewires Metabolic and Immune Response!

A new study once again confirms that reducing your caloric intake is the surest and easiest way to increase your lifespan.

The new study used data gathered by Pennington Biomedical’s CALERIE 2 (Comprehensive Assessment of the Long-Term Effects of Reducing Intake of Energy), the longest-running calorie restriction trial in humans. The new study is published in the journal Science.

“Two years of modest calorie restriction reprogrammed the pathways in fat cells that help regulate the way mitochondria generate energy, the body’s anti-inflammatory responses, and potentially longevity,” said Eric Ravussin, Ph.D., Associate Executive Director for Clinical Science at Pennington Biomedical Research Center. “In other words, calorie restriction rewires many of the metabolic and immune responses that boost lifespan and healthspan.”

Key Takeaways From This Study: 

  • The study found that people who cut their calorie intake by about 14 percent over two years generated more T cells, which play a key role in immune function and slowing the aging process. 
  • The study indicated that calorie restriction could be a potential treatment to reduce age-related inflammation and improve metabolic health.
  • Calorie restriction also reduces the levels of gene encoding platelet-activating factor acetylhydrolase (PLA2G7). Reducing PLA2G7 produces health benefits that include lowering age-related inflammation and improving metabolic health.

You can read the complete study, which was published in the Feb. 10, 2022 edition of Science, by clicking on the link.

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